The Marine Institute’s main campus is located in St. John’s, within Pippy Park. It consists of classrooms and technical laboratories in support of its Programs, a flume tank, licensed seafood processing plant, simulation facilities and a freshwater aquaculture and research and development facilities.

The Institute’s Offshore Safety and Survival Centre is located in Foxtrap, 30 kms from the Institute’s main campus. This training facility includes an international class marine firefighting unit, a survival tank with environmental simulation capabilities, a helicopter underwater escape trainer and simulated ship structure which provides a practical experience in controlling and extinguishing all types of shipboard fires.

The Holyrood Marine Base, is located in Holyrood about 45 kms for the Institute's main campus. The current facility houses the Centre for Applied Ocean Technology (CTec) and activities of the Offshore Safety and Survival Centre. Since opening in 2010, the Holyrood Marine Base has become the portal to the ocean for the Memorial Univerity community for innovative oceans education and research. Construction of a new building at the facility begin in 2020, and is anticipated to be completed in 2022.

In addition to facilities in St. John’s and surrounding area the Institute operates the Safety and Emergency Response Training (SERT) Centre located in Stephenville, which offers training courses in aviation, marine and industrial safety and emergency response.